Close this search box.


Intralesional Bleomycin Injections as treatment of vascular malformations and haemangiomas.


Haemangiomas and Vascular malformations may present at any age from birth.   The way they present may vary considerably from a minor cosmetic impairment to life threatening complications. 

The group name vascular malformation includes many conditions e.g. haemangiomas, venous malformations, arterio-venous malformations, capillary malformations, lymphatic lesions and even some mixed malformations. 

In most cases the only special investigation required is an MRI examination that defines the extent of disease and the anatomy of the region.   In some superficial lesions a clinical examination is all that is required for an accurate diagnosis and treatment plan but this will vary from case to case.

Intralesional Bleomycin as treatment of these lesions has been developed in Japan and Europe and more literature is becoming available daily.

The majority of patients complain of pain, swelling, reduced ability to perform certain tasks, major cosmetic problems, psychological stress, or bleeding. Often they have received other treatments for this condition e.g. surgery, laser, steroids, embolization, etc with varying results but seldom complete resolution and sometimes complications of these treatments.

The treatment comprises percutaneous injection of Bleomycin into the lesion. As this is a painful procedure and as multiple punctures may be required per injection session, most cases are performed under general anaesthesia. This is usually performed as a day surgery procedure, very occasionally requiring overnight hospitalisation.


The dose injected depends on the size of the lesion, age and weight of the patient - never more than 15 mg per session, to no more than 200 mg/m2 body surface area in total.  At this total dose, we have not attained half the dose that has been proven to give pulmonary complications (450 - 500 mg/m2). At average, five sessions are required at two to six weekly intervals.

As a rule, the treatment is very well tolerated by patients with a period of 24-48 hours of discomfort at the site of injection and also some swelling. If the lesion were to be in the head and neck, hands, feet, or perineum, this period of discomfort may require sick leave. 

“Put yourself at the top of your to do list.”



Centurion Cosmetic Clinic, understand that getting a plastic surgery procedure is one of your biggest life decisions. It takes time, planning, and resources. We want you to know that our Plastic Reconstructive Surgeons and the Centurion Cosmetic Clinic team are here to help you every step of the way.



Contact us for free phone consultation with one of our knowledgeable surgical consultants who are trained by our Plastic Reconstructive Surgeons. They will answer many of your questions, provide you with additional information on procedures of your interest and pro-forma quotations. You can decide if you are ready for your consultation with one of our Plastic Reconstructive Surgeons.

Consultation with Dr Paul Pienaar or Dr Liana Volkwyn

Meet your Plastic Reconstructive Surgeon during your one-on-one consultation. During the consultation the surgeon will discuss the procedure, preparations, after care and answer all additional questions. You will be provided with a personalised quotation after your consultation. The consultation fee is R 900.

Preparations & Surgery Day

After you reserve your surgery date, Centurion Cosmetic Clinic will need a 30 % deposit to secure your theatre booking at the Centurion Day Hospital. The surgeon and the Centurion Cosmetic Clinic team will make sure you are well informed and prepared for your big day. Preparation and After care are very important parts of your plastic surgery journey.

Enjoy Results

The post-op phase is an important time. The Centurion Cosmetic Clinic team will make sure you are well informed with post-op information and will arrange your first follow up appointment on the day of your surgery. You will have to visit the Centurion Cosmetic Clinic for your first follow up appointment 7 to 10 days after surgery and then again on 6 weeks after surgery. Healing and recovering are of great importance so you can enjoy your amazing results and your improved quality of life that you have envisioned.

Contact Us


We are so happy to see you here! To best serve you, please fill in the contact form below. Make sure to leave a message with all the necessary details and we will be in touch shortly! | 012 663 2011/0​